Assay Detail
Binding
CHEMBL4021376
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full length C-terminal His/FLAG-tagged human HDAC1 expressed in baculovirus infected Sf9 insect cells using BPS HDAC substrate 3 after 30 mins by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of largazole zinc-binding group analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.13 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3593247 | — | — | 1 | 9.40 |
| CHEMBL4099942 | — | — | 1 | 7.58 |
| CHEMBL4078721 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3593247 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4099942 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4078721 | — | IC50 | = | 40.0 | nM | 7.40 |