Assay Detail
Binding
CHEMBL4021437
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Inhibition of DPP8 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.32 | 4.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4067185 | — | — | 1 | 4.57 |
| CHEMBL4078112 | — | — | 1 | 4.24 |
| CHEMBL4086264 | — | — | 1 | 4.16 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | - |
| CHEMBL4090635 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4067185 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4078112 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL4086264 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL4090635 | — | IC50 | > | 100000.0 | nM | - |