Assay Detail
Binding
CHEMBL4022157
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Inhibition of HCV NS3/4A protease
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
QSAR studies of the bioactivity of hepatitis C virus (HCV) NS3/4A protease inhibitors by multiple linear regression (MLR) and support vector machine (SVM).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.11 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3391662 | PARITAPREVIR | 4.0 | 1 | 9.74 |
| CHEMBL2105735 | ASUNAPREVIR | 4.0 | 1 | 8.59 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3391662 | PARITAPREVIR | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL2105735 | ASUNAPREVIR | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL231813 | TELAPREVIR | IC50 | = | 1030.0 | nM | 5.99 |