Assay Detail
Binding
CHEMBL4022197
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full length His-tagged AKT3 expressed in baculovirus expression system using ser/thr 6 as substrate after 1 hr by FRET-based Z'-Lyte assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-gamma serine/threonine-protein kinase (CHEMBL4816) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent progress towards clinically relevant ATP-competitive Akt inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.30 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3544960 | AT-13148 | 1.0 | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3544960 | AT-13148 | IC50 | = | 50.0 | nM | 7.30 |