Assay Detail
Binding
CHEMBL4022281
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP19 in human placental microsome using [1beta-3H]-androstenedione as substrate after 15 mins in presence of NADPH by liquid scintillation counter method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Placenta |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of synthesized coumarin derivatives on aromatase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.21 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1200374 | EXEMESTANE | 4.0 | 1 | 7.37 |
| CHEMBL488 | AMINOGLUTETHIMIDE | 4.0 | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1200374 | EXEMESTANE | IC50 | = | 42.5 | nM | 7.37 |
| CHEMBL488 | AMINOGLUTETHIMIDE | IC50 | = | 9000.0 | nM | 5.05 |