Assay Detail
Binding
CHEMBL4022455
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Inhibition of Streptococcus pneumoniae sialidase NanB using 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid as substrate after 60 mins by FRET assay
23
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Streptococcus pneumoniae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.59 | 5.44 |
| Inhibition | 10 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL524100 | MALABARICONE C | — | 2 | 5.44 |
| CHEMBL489354 | MALABARICONE B | — | 2 | 5.24 |
| CHEMBL578403 | (-)-LICARIN B | — | 2 | 4.85 |
| CHEMBL4079519 | — | — | 2 | 4.68 |
| CHEMBL4072450 | — | — | 2 | 4.57 |
| CHEMBL96712 | NEU5AC2EN | — | 1 | 4.35 |
| CHEMBL2059292 | METHOXYEUGENOL | — | 2 | 4.11 |
| CHEMBL4091275 | — | — | 2 | 4.04 |
| CHEMBL463526 | LICARIN A | — | 2 | 4.02 |
| CHEMBL3601519 | — | — | 2 | - |
| CHEMBL4085435 | — | — | 2 | - |
| CHEMBL4097551 | — | — | 1 | - |
| CHEMBL481044 | ELEMICIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL524100 | MALABARICONE C | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL489354 | MALABARICONE B | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL578403 | (-)-LICARIN B | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4079519 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL4072450 | — | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL96712 | NEU5AC2EN | IC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL2059292 | METHOXYEUGENOL | IC50 | = | 77600.0 | nM | 4.11 |
| CHEMBL4091275 | — | IC50 | = | 92100.0 | nM | 4.04 |
| CHEMBL463526 | LICARIN A | IC50 | = | 95800.0 | nM | 4.02 |
| CHEMBL489354 | MALABARICONE B | Inhibition | - | % | - | |
| CHEMBL3601519 | — | Inhibition | - | % | - | |
| CHEMBL4091275 | — | Inhibition | - | % | - | |
| CHEMBL3601519 | — | IC50 | = | 331200.0 | nM | - |
| CHEMBL578403 | (-)-LICARIN B | Inhibition | - | % | - | |
| CHEMBL463526 | LICARIN A | Inhibition | - | % | - | |
| CHEMBL4079519 | — | Inhibition | - | % | - | |
| CHEMBL481044 | ELEMICIN | IC50 | - | — | - | |
| CHEMBL4085435 | — | IC50 | = | 229300.0 | nM | - |
| CHEMBL4085435 | — | Inhibition | - | % | - | |
| CHEMBL4097551 | — | IC50 | - | — | - | |
| CHEMBL524100 | MALABARICONE C | Inhibition | - | % | - | |
| CHEMBL2059292 | METHOXYEUGENOL | Inhibition | - | % | - | |
| CHEMBL4072450 | — | Inhibition | - | % | - |