Assay Detail
Functional
CHEMBL4022510
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in primary human endothelial keratinocytes assessed as inhibition of IL-17A/TNF-alpha induced IL-8 production preincubated for 2 hrs followed by cytokine addition measured after 72 hrs by HTRF assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Keratinocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The design, synthesis, and anti-inflammatory evaluation of a drug-like library based on the natural product valerenic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.32 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4088435 | — | — | 1 | 5.55 |
| CHEMBL4072446 | — | — | 1 | 5.54 |
| CHEMBL4067177 | — | — | 1 | 5.33 |
| CHEMBL4080571 | — | — | 1 | 5.31 |
| CHEMBL4102786 | — | — | 1 | 5.12 |
| CHEMBL4099378 | — | — | 1 | 5.08 |
| CHEMBL4096155 | — | — | 1 | - |
| CHEMBL4085993 | — | — | 1 | - |
| CHEMBL4103910 | — | — | 1 | - |
| CHEMBL4104798 | — | — | 1 | - |
| CHEMBL4078502 | — | — | 1 | - |
| CHEMBL1545045 | VALERENIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4088435 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4072446 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4067177 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4080571 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4102786 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4099378 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4096155 | — | IC50 | - | — | - | |
| CHEMBL4085993 | — | IC50 | - | — | - | |
| CHEMBL4103910 | — | IC50 | - | — | - | |
| CHEMBL4104798 | — | IC50 | - | — | - | |
| CHEMBL4078502 | — | IC50 | - | — | - | |
| CHEMBL1545045 | VALERENIC ACID | IC50 | - | — | - |