Assay Detail
ADMET
CHEMBL4022512
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Cytotoxicity against primary human endothelial keratinocytes assessed as inhibition of cell viability preincubated for 2 hrs followed by cytokine addition measured after 72 hrs by PrestoBlue staining based fluorescence assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Keratinocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The design, synthesis, and anti-inflammatory evaluation of a drug-like library based on the natural product valerenic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.33 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL632 | BETAMETHASONE | 4.0 | 1 | 6.52 |
| CHEMBL4088435 | — | — | 1 | 5.06 |
| CHEMBL4072446 | — | — | 1 | 5.05 |
| CHEMBL4080571 | — | — | 1 | 5.02 |
| CHEMBL4067177 | — | — | 1 | 5.02 |
| CHEMBL4096155 | — | — | 1 | - |
| CHEMBL4085993 | — | — | 1 | - |
| CHEMBL4103910 | — | — | 1 | - |
| CHEMBL4104798 | — | — | 1 | - |
| CHEMBL4099378 | — | — | 1 | - |
| CHEMBL4078502 | — | — | 1 | - |
| CHEMBL4102786 | — | — | 1 | - |
| CHEMBL1545045 | VALERENIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL632 | BETAMETHASONE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4088435 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL4072446 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4080571 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4067177 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4096155 | — | IC50 | - | — | - | |
| CHEMBL4085993 | — | IC50 | - | — | - | |
| CHEMBL4103910 | — | IC50 | - | — | - | |
| CHEMBL4104798 | — | IC50 | - | — | - | |
| CHEMBL4099378 | — | IC50 | - | — | - | |
| CHEMBL4078502 | — | IC50 | - | — | - | |
| CHEMBL4102786 | — | IC50 | - | — | - | |
| CHEMBL1545045 | VALERENIC ACID | IC50 | - | — | - |