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Assay Detail

CHEMBL4022517

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by WST8 assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities.
Nguyen HM, Ito T, Kurimoto SI, Ogawa M, Win NN, Hung VQ, Nguyen HT, Kubota T, Kobayashi J, Morita H.
Bioorg Med Chem Lett (2017) 27 : 3043 -3047
PubMed 28558970 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.18 5.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4081237 1 5.40
CHEMBL185 FLUOROURACIL 4.0 1 5.33
CHEMBL155085 ILIMAQUINONE 1 5.23
CHEMBL4062001 1 5.21
CHEMBL4062186 1 5.18
CHEMBL3309305 1 5.17
CHEMBL4064921 1 5.11
CHEMBL3309304 1 5.11
CHEMBL4099256 1 5.05
CHEMBL4091519 1 5.00
CHEMBL4086385 1 -
CHEMBL4102811 1 -
CHEMBL4073521 1 -
CHEMBL3398178 1 -
CHEMBL4089102 1 -
CHEMBL4060921 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4081237 IC50 = 4000.0 nM 5.40
CHEMBL185 FLUOROURACIL IC50 = 4700.0 nM 5.33
CHEMBL155085 ILIMAQUINONE IC50 = 5900.0 nM 5.23
CHEMBL4062001 IC50 = 6200.0 nM 5.21
CHEMBL4062186 IC50 = 6600.0 nM 5.18
CHEMBL3309305 IC50 = 6700.0 nM 5.17
CHEMBL4064921 IC50 = 7800.0 nM 5.11
CHEMBL3309304 IC50 = 7800.0 nM 5.11
CHEMBL4099256 IC50 = 8900.0 nM 5.05
CHEMBL4091519 IC50 = 9900.0 nM 5.00
CHEMBL4086385 IC50 > 50000.0 nM -
CHEMBL4102811 IC50 > 50000.0 nM -
CHEMBL4073521 IC50 > 50000.0 nM -
CHEMBL3398178 IC50 > 50000.0 nM -
CHEMBL4089102 IC50 > 50000.0 nM -
CHEMBL4060921 IC50 > 50000.0 nM -