Assay Detail
Binding
CHEMBL4022633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST fused human recombinant JAK1 (866 to 1154 amino acids) expressed in insect cells using ATP and peptide substrate (FITC-C6-KKHTDDGYMPMSPGVA-NH2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Janus-Associated Kinase 1 (JAK1) Inhibitors as Potential Treatment for Immune Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.45 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4064366 | — | — | 1 | 8.15 |
| CHEMBL4102286 | — | — | 1 | 6.07 |
| CHEMBL4078025 | — | — | 1 | 5.12 |
| CHEMBL4092807 | — | — | 1 | - |
| CHEMBL4060528 | — | — | 1 | - |
| CHEMBL4085905 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4064366 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4102286 | — | IC50 | = | 847.0 | nM | 6.07 |
| CHEMBL4078025 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4092807 | — | IC50 | < | 6.0 | nM | - |
| CHEMBL4060528 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL4085905 | — | IC50 | < | 4.0 | nM | - |