Assay Detail
Binding
CHEMBL4022637
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Inhibition of JAK1 in human NCI-H1975 cells assessed as reduction in STAT3 phosphorylation incubated for 2 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Janus-Associated Kinase 1 (JAK1) Inhibitors as Potential Treatment for Immune Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.96 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4060528 | — | — | 1 | 7.25 |
| CHEMBL4064366 | — | — | 1 | 7.24 |
| CHEMBL4085905 | — | — | 1 | 7.12 |
| CHEMBL4092807 | — | — | 1 | 6.98 |
| CHEMBL4102286 | — | — | 1 | 6.19 |
| CHEMBL4078025 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4060528 | — | IC50 | = | 56.6 | nM | 7.25 |
| CHEMBL4064366 | — | IC50 | = | 57.9 | nM | 7.24 |
| CHEMBL4085905 | — | IC50 | = | 75.1 | nM | 7.12 |
| CHEMBL4092807 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4102286 | — | IC50 | = | 643.0 | nM | 6.19 |
| CHEMBL4078025 | — | IC50 | > | 3000.0 | nM | - |