Assay Detail

CHEMBL4022642

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Binding

Binding affinity to JAK1 JH2 domain (unknown origin)

ChEMBL ↗

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Target

Tyrosine-protein kinase JAK1 (CHEMBL2835) ↗

Open DB target context

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Tyrosine-protein kinase JAK1 (CHEMBL2835) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Tyrosine-protein kinase JAK1

CHEMBL2835

Anchored from Assay target.

Protein identity Tyrosine-protein kinase JAK1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Tyrosine-protein kinase JAK1 (CHEMBL2835) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders.

Puleo DE, Kucera K, Hammarén HM, Ungureanu D, Newton AS, Silvennoinen O, Jorgensen WL, Schlessinger J.
ACS Med Chem Lett (2017) 8 : 618 -621
PubMed 28626521 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	7.68	7.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL191003	JNJ-7706621	—	1	7.68

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL191003	JNJ-7706621	Kd	=	21.0	nM	7.68