Assay Detail
Binding
CHEMBL4022683
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human GSK3 using biotin-CREB peptide substrate after 1 hr by scintillation counting method
137
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 137 | 7.35 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1080901 | — | — | 1 | 9.00 |
| CHEMBL4064262 | — | — | 1 | 9.00 |
| CHEMBL4094465 | — | — | 1 | 9.00 |
| CHEMBL3185148 | — | — | 1 | 9.00 |
| CHEMBL4072858 | — | — | 1 | 8.70 |
| CHEMBL4073905 | — | — | 1 | 8.52 |
| CHEMBL427882 | — | — | 1 | 8.40 |
| CHEMBL4094020 | — | — | 1 | 8.40 |
| CHEMBL461262 | — | — | 1 | 8.40 |
| CHEMBL4099272 | — | — | 1 | 8.40 |
| CHEMBL4083649 | — | — | 1 | 8.40 |
| CHEMBL4082639 | — | — | 1 | 8.40 |
| CHEMBL4072146 | — | — | 1 | 8.40 |
| CHEMBL412142 | LADUVIGLUSIB | 1.0 | 1 | 8.30 |
| CHEMBL4071127 | — | — | 1 | 8.30 |
| CHEMBL4098183 | — | — | 1 | 8.30 |
| CHEMBL4079611 | — | — | 1 | 8.22 |
| CHEMBL4094072 | — | — | 1 | 8.22 |
| CHEMBL4099541 | — | — | 1 | 8.22 |
| CHEMBL4101752 | — | — | 1 | 8.22 |
| CHEMBL4100641 | — | — | 1 | 8.22 |
| CHEMBL4069913 | — | — | 1 | 8.15 |
| CHEMBL4062322 | — | — | 1 | 8.15 |
| CHEMBL4083757 | — | — | 1 | 8.15 |
| CHEMBL4094913 | — | — | 1 | 8.15 |
| CHEMBL4080195 | — | — | 1 | 8.15 |
| CHEMBL4089009 | — | — | 1 | 8.15 |
| CHEMBL4085164 | — | — | 1 | 8.10 |
| CHEMBL4089838 | — | — | 1 | 8.05 |
| CHEMBL4066536 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3185148 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1080901 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4094465 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4064262 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4072858 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4073905 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4094020 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4083649 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL461262 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL427882 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4082639 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4099272 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4072146 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4071127 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4098183 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4079611 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4099541 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4094072 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4100641 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4101752 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4062322 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4083757 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4089009 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4094913 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4080195 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4069913 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4085164 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4104432 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4066536 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4089838 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4072386 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4078591 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4096710 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4061880 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4062490 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4071363 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4089404 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4080593 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4064514 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4097117 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4104825 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4084039 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4092907 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4095107 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4102872 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4090468 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4102206 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4060435 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4095193 | — | IC50 | = | 22.0 | nM | 7.66 |