Assay Detail
Functional
CHEMBL4023220
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human mGlu2 receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP formation after 20 mins by HTRF assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Pharmacological Characterization of C4β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 7.48 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4091735 | — | — | 1 | 8.42 |
| CHEMBL4070866 | — | — | 1 | 8.20 |
| CHEMBL4095567 | — | — | 1 | 8.16 |
| CHEMBL8759 | EGLUMETAD | 2.0 | 1 | 8.15 |
| CHEMBL4068189 | — | — | 1 | 8.13 |
| CHEMBL4071962 | — | — | 1 | 8.08 |
| CHEMBL4061162 | — | — | 1 | 7.80 |
| CHEMBL4090293 | — | — | 1 | 7.77 |
| CHEMBL4091203 | — | — | 1 | 7.74 |
| CHEMBL4063336 | — | — | 1 | 7.72 |
| CHEMBL4095995 | — | — | 1 | 7.70 |
| CHEMBL2381647 | — | — | 1 | 7.67 |
| CHEMBL4099470 | — | — | 1 | 7.58 |
| CHEMBL4098939 | — | — | 1 | 7.37 |
| CHEMBL4081453 | — | — | 1 | 7.32 |
| CHEMBL2381649 | — | — | 1 | 6.59 |
| CHEMBL4068679 | — | — | 1 | 6.29 |
| CHEMBL4069251 | — | — | 1 | 6.05 |
| CHEMBL4060567 | — | — | 1 | 5.47 |
| CHEMBL4093017 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4091735 | — | EC50 | = | 3.77 | nM | 8.42 |
| CHEMBL4070866 | — | EC50 | = | 6.32 | nM | 8.20 |
| CHEMBL4095567 | — | EC50 | = | 6.97 | nM | 8.16 |
| CHEMBL8759 | EGLUMETAD | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4068189 | — | EC50 | = | 7.44 | nM | 8.13 |
| CHEMBL4071962 | — | EC50 | = | 8.37 | nM | 8.08 |
| CHEMBL4061162 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4090293 | — | EC50 | = | 17.1 | nM | 7.77 |
| CHEMBL4091203 | — | EC50 | = | 18.1 | nM | 7.74 |
| CHEMBL4063336 | — | EC50 | = | 19.1 | nM | 7.72 |
| CHEMBL4095995 | — | EC50 | = | 19.8 | nM | 7.70 |
| CHEMBL2381647 | — | EC50 | = | 21.2 | nM | 7.67 |
| CHEMBL4099470 | — | EC50 | = | 26.5 | nM | 7.58 |
| CHEMBL4098939 | — | EC50 | = | 42.5 | nM | 7.37 |
| CHEMBL4081453 | — | EC50 | = | 47.5 | nM | 7.32 |
| CHEMBL2381649 | — | EC50 | = | 257.0 | nM | 6.59 |
| CHEMBL4068679 | — | EC50 | = | 508.0 | nM | 6.29 |
| CHEMBL4069251 | — | EC50 | = | 893.0 | nM | 6.05 |
| CHEMBL4060567 | — | EC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL4093017 | — | EC50 | > | 25000.0 | nM | - |