Assay Detail
Functional
CHEMBL4023799
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania donovani amastigotes expressing Luc gene infected in mouse J774A.1 cells by luciferase reporter gene assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 6.19 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4067816 | — | — | 1 | 7.22 |
| CHEMBL4097686 | — | — | 1 | 6.92 |
| CHEMBL4093258 | — | — | 1 | 6.85 |
| CHEMBL4090381 | — | — | 1 | 6.82 |
| CHEMBL4092525 | — | — | 1 | 6.77 |
| CHEMBL4064066 | — | — | 1 | 6.75 |
| CHEMBL4102643 | — | — | 1 | 6.75 |
| CHEMBL4078293 | — | — | 1 | 6.72 |
| CHEMBL4061728 | — | — | 1 | 6.68 |
| CHEMBL4068473 | — | — | 1 | 6.64 |
| CHEMBL3608844 | — | — | 1 | 6.64 |
| CHEMBL4098597 | — | — | 1 | 6.62 |
| CHEMBL4063124 | — | — | 1 | 6.58 |
| CHEMBL4065592 | — | — | 1 | 6.57 |
| CHEMBL4071737 | — | — | 1 | 6.51 |
| CHEMBL4061272 | — | — | 1 | 6.51 |
| CHEMBL572070 | — | — | 1 | 6.44 |
| CHEMBL4086552 | — | — | 1 | 6.41 |
| CHEMBL450548 | — | — | 1 | 6.41 |
| CHEMBL1836005 | — | — | 1 | 6.41 |
| CHEMBL3608846 | — | — | 1 | 6.34 |
| CHEMBL4073834 | — | — | 1 | 6.32 |
| CHEMBL4084773 | — | — | 1 | 6.20 |
| CHEMBL4067944 | — | — | 1 | 6.19 |
| CHEMBL4087531 | — | — | 1 | 6.11 |
| CHEMBL4097042 | — | — | 1 | 6.11 |
| CHEMBL4095234 | — | — | 1 | 6.07 |
| CHEMBL4102045 | — | — | 1 | 6.07 |
| CHEMBL480375 | — | — | 1 | 5.96 |
| CHEMBL4095902 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4067816 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4097686 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4093258 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4090381 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4092525 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4064066 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4102643 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4078293 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4061728 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4068473 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3608844 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4098597 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4063124 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4065592 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4061272 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4071737 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL572070 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4086552 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL450548 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1836005 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3608846 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4073834 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4084773 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4067944 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4087531 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4097042 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4095234 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4102045 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL480375 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4095902 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4065114 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1836062 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3608850 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3608849 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1946794 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL227875 | PRETOMANID | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4105398 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4091750 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4076532 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4070883 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL4067141 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4088403 | — | IC50 | > | 2000.0 | nM | - |