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Assay Detail

CHEMBL4023800

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Functional
Antileishmanial activity against Leishmania infantum amastigotes infected in mouse primary peritoneal macrophages after 5 days by Giemsa staining based microscopic method
ChEMBL ↗
92
Total Activities
92
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania infantum
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania infantum (CHEMBL612848) ↗
Type ORGANISM
Organism Leishmania infantum

Publication

Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis.
Thompson AM, O'Connor PD, Marshall AJ, Blaser A, Yardley V, Maes L, Gupta S, Launay D, Braillard S, Chatelain E, Wan B, Franzblau SG, Ma Z, Cooper CB, Denny WA.
J Med Chem (2018) 61 : 2329 -2352
PubMed 29461823 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 92 5.63 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4085479 — — 1 6.89
CHEMBL4103409 — — 1 6.70
CHEMBL4101663 — — 1 6.51
CHEMBL4077167 — — 1 6.48
CHEMBL4100012 — — 1 6.39
CHEMBL4065586 — — 1 6.37
CHEMBL4085508 — — 1 6.36
CHEMBL4089957 — — 1 6.35
CHEMBL4079653 — — 1 6.29
CHEMBL4063931 — — 1 6.28
CHEMBL4078293 — — 1 6.28
CHEMBL4061272 — — 1 6.24
CHEMBL4065592 — — 1 6.21
CHEMBL4065239 — — 1 6.21
CHEMBL4067816 — — 1 6.20
CHEMBL4102045 — — 1 6.20
CHEMBL4076665 — — 1 6.19
CHEMBL4100963 — — 1 6.19
CHEMBL4098597 — — 1 6.15
CHEMBL4097686 — — 1 6.14
CHEMBL4074208 — — 1 6.08
CHEMBL4098109 — — 1 6.07
CHEMBL4067944 — — 1 6.07
CHEMBL4093258 — — 1 6.06
CHEMBL4061728 — — 1 6.06
CHEMBL1836005 — — 1 6.02
CHEMBL4092525 — — 1 5.96
CHEMBL4090381 — — 1 5.96
CHEMBL4073834 — — 1 5.96
CHEMBL4062393 — — 1 5.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4085479 — IC50 = 130.0 nM 6.89
CHEMBL4103409 — IC50 = 200.0 nM 6.70
CHEMBL4101663 — IC50 = 310.0 nM 6.51
CHEMBL4077167 — IC50 = 330.0 nM 6.48
CHEMBL4100012 — IC50 = 410.0 nM 6.39
CHEMBL4065586 — IC50 = 430.0 nM 6.37
CHEMBL4085508 — IC50 = 440.0 nM 6.36
CHEMBL4089957 — IC50 = 450.0 nM 6.35
CHEMBL4079653 — IC50 = 510.0 nM 6.29
CHEMBL4063931 — IC50 = 530.0 nM 6.28
CHEMBL4078293 — IC50 = 530.0 nM 6.28
CHEMBL4061272 — IC50 = 570.0 nM 6.24
CHEMBL4065592 — IC50 = 620.0 nM 6.21
CHEMBL4065239 — IC50 = 610.0 nM 6.21
CHEMBL4102045 — IC50 = 630.0 nM 6.20
CHEMBL4067816 — IC50 = 630.0 nM 6.20
CHEMBL4076665 — IC50 = 640.0 nM 6.19
CHEMBL4100963 — IC50 = 650.0 nM 6.19
CHEMBL4098597 — IC50 = 710.0 nM 6.15
CHEMBL4097686 — IC50 = 730.0 nM 6.14
CHEMBL4074208 — IC50 = 830.0 nM 6.08
CHEMBL4098109 — IC50 = 850.0 nM 6.07
CHEMBL4067944 — IC50 = 850.0 nM 6.07
CHEMBL4093258 — IC50 = 870.0 nM 6.06
CHEMBL4061728 — IC50 = 870.0 nM 6.06
CHEMBL1836005 — IC50 = 950.0 nM 6.02
CHEMBL4090381 — IC50 = 1100.0 nM 5.96
CHEMBL4073834 — IC50 = 1100.0 nM 5.96
CHEMBL4092525 — IC50 = 1100.0 nM 5.96
CHEMBL4062393 — IC50 = 1200.0 nM 5.92
CHEMBL4086552 — IC50 = 1200.0 nM 5.92
CHEMBL4062862 — IC50 = 1400.0 nM 5.85
CHEMBL4100987 — IC50 = 1400.0 nM 5.85
CHEMBL4091825 — IC50 = 1400.0 nM 5.85
CHEMBL4071564 — IC50 = 1600.0 nM 5.80
CHEMBL3608849 — IC50 = 1700.0 nM 5.77
CHEMBL4078826 — IC50 = 1900.0 nM 5.72
CHEMBL4086678 — IC50 = 1900.0 nM 5.72
CHEMBL4095234 — IC50 = 2000.0 nM 5.70
CHEMBL4087531 — IC50 = 2000.0 nM 5.70
CHEMBL4083095 — IC50 = 2100.0 nM 5.68
CHEMBL4091750 — IC50 = 2200.0 nM 5.66
CHEMBL4071737 — IC50 = 2300.0 nM 5.64
CHEMBL4064066 — IC50 = 2300.0 nM 5.64
CHEMBL4087650 — IC50 = 2300.0 nM 5.64
CHEMBL4068863 — IC50 = 2400.0 nM 5.62
CHEMBL4097042 — IC50 = 2500.0 nM 5.60
CHEMBL4090795 — IC50 = 2500.0 nM 5.60
CHEMBL3608850 — IC50 = 2600.0 nM 5.58
CHEMBL4105533 — IC50 = 2800.0 nM 5.55