Assay Detail
ADMET
CHEMBL4023803
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Cytotoxicity against human MRC5 cells after 72 hrs by resazurin dye based assay
93
Total Activities
93
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 93 | 4.45 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4072660 | — | — | 1 | 4.85 |
| CHEMBL4068473 | — | — | 1 | 4.80 |
| CHEMBL4065239 | — | — | 1 | 4.77 |
| CHEMBL4085508 | — | — | 1 | 4.55 |
| CHEMBL4061272 | — | — | 1 | 4.39 |
| CHEMBL4076665 | — | — | 1 | 4.38 |
| CHEMBL4095813 | — | — | 1 | 4.32 |
| CHEMBL4084773 | — | — | 1 | 4.24 |
| CHEMBL4061728 | — | — | 1 | 4.24 |
| CHEMBL4071737 | — | — | 1 | 4.21 |
| CHEMBL4067816 | — | — | 1 | 4.21 |
| CHEMBL4065586 | — | — | 1 | - |
| CHEMBL4062862 | — | — | 1 | - |
| CHEMBL4090795 | — | — | 1 | - |
| CHEMBL4100987 | — | — | 1 | - |
| CHEMBL1836062 | — | — | 1 | - |
| CHEMBL4093258 | — | — | 1 | - |
| CHEMBL4077167 | — | — | 1 | - |
| CHEMBL4063931 | — | — | 1 | - |
| CHEMBL4097615 | — | — | 1 | - |
| CHEMBL4078293 | — | — | 1 | - |
| CHEMBL4069505 | — | — | 1 | - |
| CHEMBL4062393 | — | — | 1 | - |
| CHEMBL4089478 | — | — | 1 | - |
| CHEMBL4098109 | — | — | 1 | - |
| CHEMBL4071028 | — | — | 1 | - |
| CHEMBL4090381 | — | — | 1 | - |
| CHEMBL4065451 | — | — | 1 | - |
| CHEMBL4081599 | — | — | 1 | - |
| CHEMBL1946794 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4072660 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4068473 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4065239 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4085508 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4061272 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL4076665 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL4095813 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL4084773 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL4061728 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL4071737 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL4067816 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL4076532 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4074828 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL512244 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL227875 | PRETOMANID | IC50 | > | 64000.0 | nM | - |
| CHEMBL4074208 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4100963 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4084507 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4075618 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4103409 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4085479 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4101511 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4100012 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4101663 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4088088 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL1944881 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4080211 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4098235 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4078826 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL1944704 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4078293 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL1946794 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4081599 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4065451 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4090381 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4071028 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4098109 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4089478 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4062393 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4069505 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4083095 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4097615 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4063931 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4077167 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4093258 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL1836062 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4100987 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4090795 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4062862 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4065586 | — | IC50 | > | 64000.0 | nM | - |