Assay Detail
Binding
CHEMBL4023921
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human CA9 catalytic domain expressed in mammalian expression system assessed as intrinsic thermodynamic equilibrium constant at pH 7 by SPR assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 17 | 9.34 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2010994 | — | — | 1 | 10.10 |
| CHEMBL2011156 | — | — | 1 | 9.89 |
| CHEMBL3797385 | — | — | 1 | 9.82 |
| CHEMBL3797893 | — | — | 1 | 9.77 |
| CHEMBL3359179 | — | — | 1 | 9.74 |
| CHEMBL2333416 | — | — | 1 | 9.60 |
| CHEMBL3798473 | — | — | 1 | 9.47 |
| CHEMBL3799577 | — | — | 1 | 9.24 |
| CHEMBL3798446 | — | — | 1 | 9.22 |
| CHEMBL2443188 | — | — | 1 | 9.05 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 9.00 |
| CHEMBL3799945 | — | — | 1 | 8.89 |
| CHEMBL3799296 | — | — | 1 | 8.89 |
| CHEMBL2011155 | — | — | 1 | 8.85 |
| CHEMBL1272187 | — | — | 1 | 8.59 |
| CHEMBL3359181 | — | — | 1 | - |
| CHEMBL2443189 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2010994 | — | Kd | = | 0.08 | nM | 10.10 |
| CHEMBL2011156 | — | Kd | = | 0.13 | nM | 9.89 |
| CHEMBL3797385 | — | Kd | = | 0.15 | nM | 9.82 |
| CHEMBL3797893 | — | Kd | = | 0.17 | nM | 9.77 |
| CHEMBL3359179 | — | Kd | = | 0.18 | nM | 9.74 |
| CHEMBL2333416 | — | Kd | = | 0.25 | nM | 9.60 |
| CHEMBL3798473 | — | Kd | = | 0.34 | nM | 9.47 |
| CHEMBL3799577 | — | Kd | = | 0.58 | nM | 9.24 |
| CHEMBL3798446 | — | Kd | = | 0.6 | nM | 9.22 |
| CHEMBL2443188 | — | Kd | = | 0.89 | nM | 9.05 |
| CHEMBL20 | ACETAZOLAMIDE | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL3799945 | — | Kd | = | 1.3 | nM | 8.89 |
| CHEMBL3799296 | — | Kd | = | 1.3 | nM | 8.89 |
| CHEMBL2011155 | — | Kd | = | 1.4 | nM | 8.85 |
| CHEMBL1272187 | — | Kd | = | 2.6 | nM | 8.59 |
| CHEMBL3359181 | — | Kd | = | 0.00019 | nM | - |
| CHEMBL2443189 | — | Kd | = | 0.33 | nM | - |