Assay Detail
Binding
CHEMBL4023923
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Binding affinity to human full length His-tagged CA2 (1 to 260 residues) expressed in Escherichia coli BL21(DE3) assessed as thermodynamic equilibrium constant at pH 7 by SPR assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.17 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.82 |
| CHEMBL2010994 | — | — | 1 | 7.29 |
| CHEMBL4085190 | — | — | 1 | 7.21 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | 3.0 | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL2010994 | — | Kd | = | 51.4 | nM | 7.29 |
| CHEMBL4085190 | — | Kd | = | 61.0 | nM | 7.21 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Kd | = | 430.0 | nM | 6.37 |