Assay Detail
Binding
CHEMBL4023926
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Binding affinity to human full length His-tagged CA2 (1 to 260 residues) expressed in Escherichia coli BL21(DE3) assessed as intrinsic thermodynamic equilibrium constant at pH 7 by SPR assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 16 | 9.11 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2443188 | — | — | 1 | 9.96 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | 3.0 | 1 | 9.89 |
| CHEMBL3798446 | — | — | 1 | 9.89 |
| CHEMBL2010994 | — | — | 1 | 9.72 |
| CHEMBL3797893 | — | — | 1 | 9.72 |
| CHEMBL3799577 | — | — | 1 | 9.41 |
| CHEMBL3799945 | — | — | 1 | 9.00 |
| CHEMBL2443189 | — | — | 1 | 8.96 |
| CHEMBL3799296 | — | — | 1 | 8.89 |
| CHEMBL2011155 | — | — | 1 | 8.82 |
| CHEMBL4085190 | — | — | 1 | 8.70 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.59 |
| CHEMBL1272242 | — | — | 1 | 8.51 |
| CHEMBL3359181 | — | — | 1 | 8.32 |
| CHEMBL1272187 | — | — | 1 | 8.31 |
| CHEMBL2011156 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2443188 | — | Kd | = | 0.11 | nM | 9.96 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Kd | = | 0.13 | nM | 9.89 |
| CHEMBL3798446 | — | Kd | = | 0.13 | nM | 9.89 |
| CHEMBL2010994 | — | Kd | = | 0.19 | nM | 9.72 |
| CHEMBL3797893 | — | Kd | = | 0.19 | nM | 9.72 |
| CHEMBL3799577 | — | Kd | = | 0.39 | nM | 9.41 |
| CHEMBL3799945 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL2443189 | — | Kd | = | 1.1 | nM | 8.96 |
| CHEMBL3799296 | — | Kd | = | 1.3 | nM | 8.89 |
| CHEMBL2011155 | — | Kd | = | 1.5 | nM | 8.82 |
| CHEMBL4085190 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL20 | ACETAZOLAMIDE | Kd | = | 2.6 | nM | 8.59 |
| CHEMBL1272242 | — | Kd | = | 3.1 | nM | 8.51 |
| CHEMBL3359181 | — | Kd | = | 4.8 | nM | 8.32 |
| CHEMBL1272187 | — | Kd | = | 4.9 | nM | 8.31 |
| CHEMBL2011156 | — | Kd | = | 0.017 | nM | - |