Assay Detail
Binding
CHEMBL4023932
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Binding affinity to human N-terminal full length His-tagged CA13 (1 to 262 residues) expressed in Escherichia coli BL21(DE3) assessed as intrinsic thermodynamic equilibrium constant at pH 7 by SPR assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 18 | 9.01 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2333416 | — | — | 1 | 10.30 |
| CHEMBL2010994 | — | — | 1 | 10.24 |
| CHEMBL2443188 | — | — | 1 | 9.77 |
| CHEMBL3798446 | — | — | 1 | 9.72 |
| CHEMBL3797385 | — | — | 1 | 9.37 |
| CHEMBL3799577 | — | — | 1 | 9.35 |
| CHEMBL2011156 | — | — | 1 | 9.28 |
| CHEMBL3798473 | — | — | 1 | 9.08 |
| CHEMBL3797893 | — | — | 1 | 9.04 |
| CHEMBL4085190 | — | — | 1 | 9.00 |
| CHEMBL3359179 | — | — | 1 | 9.00 |
| CHEMBL3359181 | — | — | 1 | 8.70 |
| CHEMBL3799296 | — | — | 1 | 8.64 |
| CHEMBL2443189 | — | — | 1 | 8.40 |
| CHEMBL2011155 | — | — | 1 | 8.25 |
| CHEMBL3799945 | — | — | 1 | 8.06 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.00 |
| CHEMBL1272242 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2333416 | — | Kd | = | 0.05 | nM | 10.30 |
| CHEMBL2010994 | — | Kd | = | 0.058 | nM | 10.24 |
| CHEMBL2443188 | — | Kd | = | 0.17 | nM | 9.77 |
| CHEMBL3798446 | — | Kd | = | 0.19 | nM | 9.72 |
| CHEMBL3797385 | — | Kd | = | 0.43 | nM | 9.37 |
| CHEMBL3799577 | — | Kd | = | 0.45 | nM | 9.35 |
| CHEMBL2011156 | — | Kd | = | 0.53 | nM | 9.28 |
| CHEMBL3798473 | — | Kd | = | 0.83 | nM | 9.08 |
| CHEMBL3797893 | — | Kd | = | 0.91 | nM | 9.04 |
| CHEMBL4085190 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL3359179 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL3359181 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL3799296 | — | Kd | = | 2.3 | nM | 8.64 |
| CHEMBL2443189 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL2011155 | — | Kd | = | 5.6 | nM | 8.25 |
| CHEMBL3799945 | — | Kd | = | 8.7 | nM | 8.06 |
| CHEMBL20 | ACETAZOLAMIDE | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL1272242 | — | Kd | = | 13.0 | nM | 7.89 |