Assay Detail
Binding
CHEMBL4023964
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Binding affinity to human BAP-tagged AMPK alpha1/beta1/gamma1 by SPR assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 (CHEMBL2111345) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 14 | 7.27 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3891221 | — | — | 1 | 8.05 |
| CHEMBL3970868 | — | — | 1 | 7.85 |
| CHEMBL4105032 | — | — | 1 | 7.85 |
| CHEMBL3986871 | — | — | 1 | 7.85 |
| CHEMBL3959148 | — | — | 1 | 7.70 |
| CHEMBL3891932 | — | — | 1 | 7.66 |
| CHEMBL3931350 | — | — | 1 | 7.32 |
| CHEMBL3928208 | — | — | 1 | 7.32 |
| CHEMBL4097332 | — | — | 1 | 6.39 |
| CHEMBL4079303 | — | — | 1 | 6.24 |
| CHEMBL4087189 | — | — | 1 | 5.77 |
| CHEMBL3921758 | — | — | 1 | - |
| CHEMBL3985144 | — | — | 1 | - |
| CHEMBL4059813 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3891221 | — | Kd | = | 9.0 | nM | 8.05 |
| CHEMBL3970868 | — | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL4105032 | — | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL3986871 | — | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL3959148 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL3891932 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL3931350 | — | Kd | = | 48.0 | nM | 7.32 |
| CHEMBL3928208 | — | Kd | = | 48.0 | nM | 7.32 |
| CHEMBL4097332 | — | Kd | = | 410.0 | nM | 6.39 |
| CHEMBL4079303 | — | Kd | = | 580.0 | nM | 6.24 |
| CHEMBL4087189 | — | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL3921758 | — | Kd | - | — | - | |
| CHEMBL3985144 | — | Kd | - | — | - | |
| CHEMBL4059813 | — | Kd | - | — | - |