Assay Detail
Binding
CHEMBL4024147
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcine brain tubulin polymerization measured every 60 secs for 90 mins by DAPI staining based fluorescence assay
7
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and Biological Evaluation of Selenium-Containing 4-Anilinoquinazoline Derivatives as Novel Antimitotic Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.67 | 5.90 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4076686 | — | — | 2 | 5.90 |
| CHEMBL4096662 | — | — | 2 | 5.72 |
| CHEMBL492399 | VERUBULIN | 2.0 | 1 | 5.56 |
| CHEMBL4073184 | — | — | 2 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4076686 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4096662 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL492399 | VERUBULIN | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL4073184 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL4073184 | — | Inhibition | - | % | - | |
| CHEMBL4096662 | — | Inhibition | - | % | - | |
| CHEMBL4076686 | — | Inhibition | - | % | - |