Assay Detail
Functional
CHEMBL4024305
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Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | 4T1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N1-(4-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7 H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)phenyl)- N8-hydroxyoctanediamide as a Novel Inhibitor Targeting Cyclin-dependent Kinase 4/9 (CDK4/9) and Histone Deacetlyase1 (HDAC1) against Malignant Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.64 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4063500 | — | — | 1 | 5.96 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.32 |
| CHEMBL3545110 | RIBOCICLIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4063500 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL3545110 | RIBOCICLIB | IC50 | > | 10000.0 | nM | - |