Assay Detail
Binding
CHEMBL4024306
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Inhibition of HDAC1 (unknown origin)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of N1-(4-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7 H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)phenyl)- N8-hydroxyoctanediamide as a Novel Inhibitor Targeting Cyclin-dependent Kinase 4/9 (CDK4/9) and Histone Deacetlyase1 (HDAC1) against Malignant Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.07 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4094507 | — | — | 1 | 9.28 |
| CHEMBL4069404 | — | — | 1 | 9.08 |
| CHEMBL4068308 | — | — | 1 | 8.85 |
| CHEMBL4102249 | — | — | 1 | 8.80 |
| CHEMBL4083345 | — | — | 1 | 8.80 |
| CHEMBL4063500 | — | — | 1 | 8.66 |
| CHEMBL4074698 | — | — | 1 | 8.59 |
| CHEMBL4091353 | — | — | 1 | 8.52 |
| CHEMBL4067088 | — | — | 1 | 8.51 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.57 |
| CHEMBL4090436 | — | — | 1 | 7.57 |
| CHEMBL4082598 | — | — | 1 | 7.43 |
| CHEMBL4066630 | — | — | 1 | 7.41 |
| CHEMBL4091971 | — | — | 1 | 7.28 |
| CHEMBL4084219 | — | — | 1 | 6.37 |
| CHEMBL4066089 | — | — | 1 | 6.36 |
| CHEMBL4072827 | — | — | 1 | - |
| CHEMBL4092039 | — | — | 1 | - |
| CHEMBL4102189 | — | — | 1 | - |
| CHEMBL4073881 | — | — | 1 | - |
| CHEMBL4095168 | — | — | 1 | - |
| CHEMBL4087464 | — | — | 1 | - |
| CHEMBL4092722 | — | — | 1 | - |
| CHEMBL4071369 | — | — | 1 | - |
| CHEMBL4065039 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4094507 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL4069404 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL4068308 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4102249 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4083345 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4063500 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4074698 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4091353 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4067088 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4090436 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4082598 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4066630 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4091971 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4084219 | — | IC50 | = | 423.0 | nM | 6.37 |
| CHEMBL4066089 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL4072827 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4092039 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4102189 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4073881 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4095168 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4087464 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4092722 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4071369 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4065039 | — | IC50 | > | 5000.0 | nM | - |