Assay Detail
Binding
CHEMBL4024496
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Binding affinity to ARID/PHD1/Zn binding domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli by ITC
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 6.45 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4096760 | — | — | 1 | 7.22 |
| CHEMBL4081571 | — | — | 1 | 6.82 |
| CHEMBL4090351 | — | — | 1 | 6.75 |
| CHEMBL4070992 | — | — | 1 | 6.68 |
| CHEMBL4062359 | — | — | 1 | 6.66 |
| CHEMBL4066179 | — | — | 1 | 6.60 |
| CHEMBL4077310 | — | — | 1 | 6.39 |
| CHEMBL4059617 | — | — | 1 | 6.33 |
| CHEMBL4100530 | — | — | 1 | 6.28 |
| CHEMBL4088737 | — | — | 1 | 5.62 |
| CHEMBL4078388 | — | — | 1 | 5.57 |
| CHEMBL4067490 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4096760 | — | Kd | = | 60.0 | nM | 7.22 |
| CHEMBL4081571 | — | Kd | = | 150.0 | nM | 6.82 |
| CHEMBL4090351 | — | Kd | = | 180.0 | nM | 6.75 |
| CHEMBL4070992 | — | Kd | = | 210.0 | nM | 6.68 |
| CHEMBL4062359 | — | Kd | = | 220.0 | nM | 6.66 |
| CHEMBL4066179 | — | Kd | = | 250.0 | nM | 6.60 |
| CHEMBL4077310 | — | Kd | = | 410.0 | nM | 6.39 |
| CHEMBL4059617 | — | Kd | = | 470.0 | nM | 6.33 |
| CHEMBL4100530 | — | Kd | = | 530.0 | nM | 6.28 |
| CHEMBL4088737 | — | Kd | = | 2400.0 | nM | 5.62 |
| CHEMBL4078388 | — | Kd | = | 2700.0 | nM | 5.57 |
| CHEMBL4067490 | — | Kd | > | 12000.0 | nM | - |