Assay Detail
Binding
CHEMBL4024503
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ARID/PHD1 domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli using H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins in presence of 0.1 mM alpha-KG by FDH coupled assat
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.29 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4088737 | — | — | 1 | 5.62 |
| CHEMBL4067490 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4088737 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4067490 | — | IC50 | = | 11000.0 | nM | 4.96 |