Assay Detail
ADMET
CHEMBL4024633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length His6-tagged BRAF (unknown origin) expressed in baculovirus expression system assessed as reduction in MEK phosphorylation by measuring ADP production by BRAMA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4,6-Diaminopyrimidines as Highly Preferred Troponin I-Interacting Kinase (TNNI3K) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.82 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4087038 | — | — | 1 | 7.89 |
| CHEMBL4102486 | — | — | 1 | 7.70 |
| CHEMBL4074231 | — | — | 1 | 6.70 |
| CHEMBL4094739 | — | — | 1 | 6.60 |
| CHEMBL4070430 | — | — | 1 | 6.30 |
| CHEMBL4091362 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4087038 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4102486 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4074231 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4094739 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4070430 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4091362 | — | IC50 | = | 2000.0 | nM | 5.70 |