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Assay Detail

CHEMBL4024836

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against rhinovirus serotype 14 infected in human H1HeLa cells after 2 days by XTT/PMS dye based assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism rhinovirus B14
Confidence 1 — Organism
Curated By Autocuration

Target

rhinovirus B14 (CHEMBL613759)
Type ORGANISM
Organism rhinovirus B14

Publication

Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions.
Jackson PA, Widen JC, Harki DA, Brummond KM.
J Med Chem (2017) 60 : 839 -885
PubMed 27996267 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 5.52 6.27

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL19648 1 6.27
CHEMBL96388 1 6.15
CHEMBL96330 1 5.89
CHEMBL318039 1 5.80
CHEMBL96553 1 5.75
CHEMBL95000 1 5.70
CHEMBL94740 1 5.52
CHEMBL262762 1 5.40
CHEMBL94980 1 5.38
CHEMBL94660 1 5.28
CHEMBL94688 1 4.80
CHEMBL329736 1 4.25
CHEMBL96933 1 -
CHEMBL96445 1 -
CHEMBL95181 1 -
CHEMBL4081553 1 -
CHEMBL97329 1 -
CHEMBL319844 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL19648 EC50 = 540.0 nM 6.27
CHEMBL96388 EC50 = 710.0 nM 6.15
CHEMBL96330 EC50 = 1300.0 nM 5.89
CHEMBL318039 EC50 = 1600.0 nM 5.80
CHEMBL96553 EC50 = 1800.0 nM 5.75
CHEMBL95000 EC50 = 2000.0 nM 5.70
CHEMBL94740 EC50 = 3000.0 nM 5.52
CHEMBL262762 EC50 = 4000.0 nM 5.40
CHEMBL94980 EC50 = 4200.0 nM 5.38
CHEMBL94660 EC50 = 5200.0 nM 5.28
CHEMBL94688 EC50 = 16000.0 nM 4.80
CHEMBL329736 EC50 = 56000.0 nM 4.25
CHEMBL96933 EC50 > 320000.0 nM -
CHEMBL96445 EC50 > 100000.0 nM -
CHEMBL95181 EC50 > 320000.0 nM -
CHEMBL4081553 EC50 > 44000.0 nM -
CHEMBL97329 EC50 > 25000.0 nM -
CHEMBL319844 EC50 > 32000.0 nM -