Assay Detail
Binding
CHEMBL4024845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CRM1-mediated nucleocytoplasmic transport in human HeLa cells after 90 mins by immunofluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.20 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL486133 | LEPTOMYCIN B | — | 1 | 9.00 |
| CHEMBL4088268 | — | — | 1 | 8.00 |
| CHEMBL4077955 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL486133 | LEPTOMYCIN B | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4088268 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4077955 | — | IC50 | = | 25.0 | nM | 7.60 |