Assay Detail
Binding
CHEMBL4024906
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of highly potent and selective PI3Kδ inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 8.65 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4080090 | — | — | 1 | 9.52 |
| CHEMBL4061320 | — | — | 1 | 9.52 |
| CHEMBL4097187 | — | — | 1 | 9.40 |
| CHEMBL4090297 | — | — | 1 | 9.40 |
| CHEMBL4060977 | — | — | 1 | 9.40 |
| CHEMBL4089489 | — | — | 1 | 9.30 |
| CHEMBL4077248 | — | — | 1 | 9.22 |
| CHEMBL4071039 | — | — | 1 | 9.15 |
| CHEMBL3805348 | — | — | 1 | 9.10 |
| CHEMBL4081613 | — | — | 1 | 9.10 |
| CHEMBL4105636 | — | — | 1 | 9.10 |
| CHEMBL4065999 | — | — | 1 | 9.10 |
| CHEMBL4077544 | — | — | 1 | 9.05 |
| CHEMBL4076745 | — | — | 1 | 9.00 |
| CHEMBL4072098 | — | — | 1 | 9.00 |
| CHEMBL4101245 | — | — | 1 | 9.00 |
| CHEMBL4092654 | — | — | 1 | 8.96 |
| CHEMBL4084394 | — | — | 1 | 8.85 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 8.70 |
| CHEMBL4067250 | — | — | 1 | 8.62 |
| CHEMBL4069993 | — | — | 1 | 8.39 |
| CHEMBL4093593 | — | — | 1 | 8.31 |
| CHEMBL4067592 | — | — | 1 | 8.13 |
| CHEMBL4071877 | — | — | 1 | 8.03 |
| CHEMBL4061641 | — | — | 1 | 8.01 |
| CHEMBL4063245 | — | — | 1 | 7.96 |
| CHEMBL4084897 | — | — | 1 | 7.82 |
| CHEMBL4105190 | — | — | 1 | 7.64 |
| CHEMBL4080945 | — | — | 1 | 7.57 |
| CHEMBL4089756 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4080090 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4061320 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4090297 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4060977 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4097187 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4089489 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4077248 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4071039 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4105636 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4065999 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4081613 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3805348 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4077544 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4101245 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4072098 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4076745 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4092654 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4084394 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4067250 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4069993 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL4093593 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4067592 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4071877 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL4061641 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL4063245 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4084897 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4105190 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4080945 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4089756 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4086343 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4088828 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4069213 | — | IC50 | < | 0.3 | nM | - |
| CHEMBL4096456 | — | IC50 | < | 0.3 | nM | - |
| CHEMBL4099608 | — | IC50 | < | 0.3 | nM | - |
| CHEMBL4091875 | — | IC50 | < | 0.2 | nM | - |