Assay Detail
Binding
CHEMBL4024907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kgamma (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of highly potent and selective PI3Kδ inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.27 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4071877 | — | — | 1 | 8.33 |
| CHEMBL3805348 | — | — | 1 | 7.92 |
| CHEMBL4089756 | — | — | 1 | 7.80 |
| CHEMBL4092654 | — | — | 1 | 7.70 |
| CHEMBL4086343 | — | — | 1 | 7.57 |
| CHEMBL4080945 | — | — | 1 | 7.54 |
| CHEMBL4093593 | — | — | 1 | 7.21 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 7.20 |
| CHEMBL4088828 | — | — | 1 | 7.00 |
| CHEMBL4067592 | — | — | 1 | 6.89 |
| CHEMBL4063245 | — | — | 1 | 6.82 |
| CHEMBL4084897 | — | — | 1 | 6.72 |
| CHEMBL4061641 | — | — | 1 | 6.66 |
| CHEMBL4105190 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4071877 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL3805348 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4089756 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4092654 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4086343 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4080945 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4093593 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4088828 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL4067592 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4063245 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4084897 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4061641 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4105190 | — | IC50 | = | 390.0 | nM | 6.41 |