Assay Detail
Binding
CHEMBL4024911
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta in ACD-treated human whole blood assessed as reduction in CD69 expression measured after 1 hr
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of highly potent and selective PI3Kδ inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.14 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4091875 | — | — | 1 | 8.15 |
| CHEMBL4096456 | — | — | 1 | 7.89 |
| CHEMBL4061320 | — | — | 1 | 7.58 |
| CHEMBL4071039 | — | — | 1 | 7.52 |
| CHEMBL4105636 | — | — | 1 | 7.52 |
| CHEMBL4077248 | — | — | 1 | 7.50 |
| CHEMBL4089489 | — | — | 1 | 7.48 |
| CHEMBL4099608 | — | — | 1 | 7.46 |
| CHEMBL4090297 | — | — | 1 | 7.38 |
| CHEMBL4072098 | — | — | 1 | 7.36 |
| CHEMBL4080090 | — | — | 1 | 7.35 |
| CHEMBL4065999 | — | — | 1 | 7.35 |
| CHEMBL4060977 | — | — | 1 | 7.30 |
| CHEMBL4084394 | — | — | 1 | 7.11 |
| CHEMBL4077544 | — | — | 1 | 7.11 |
| CHEMBL4081613 | — | — | 1 | 7.04 |
| CHEMBL4076745 | — | — | 1 | 6.92 |
| CHEMBL4101245 | — | — | 1 | 6.89 |
| CHEMBL4067250 | — | — | 1 | 6.77 |
| CHEMBL4069993 | — | — | 1 | 6.62 |
| CHEMBL4097187 | — | — | 1 | 6.62 |
| CHEMBL4069213 | — | — | 1 | 6.58 |
| CHEMBL4092654 | — | — | 1 | 6.54 |
| CHEMBL4093593 | — | — | 1 | 6.41 |
| CHEMBL4086343 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4091875 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4096456 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4061320 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4071039 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4105636 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4077248 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4089489 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4099608 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4090297 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4072098 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4080090 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4065999 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4060977 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4084394 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4077544 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4081613 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL4076745 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4101245 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4067250 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4069993 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4097187 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4069213 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4092654 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4093593 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4086343 | — | IC50 | = | 1000.0 | nM | 6.00 |