Assay Detail
Functional
CHEMBL4025647
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Cytotoxicity against human NCI-H460 cells pretreated for 24 hrs under hypoxic condition followed by compound washout measured after 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of hypoxia-activated prodrugs of SN-38.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.06 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 7.22 |
| CHEMBL4079921 | — | — | 1 | 6.85 |
| CHEMBL4059463 | — | — | 1 | 5.12 |
| CHEMBL260046 | EVOFOSFAMIDE | 3.0 | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4079921 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4059463 | — | IC50 | = | 7560.0 | nM | 5.12 |
| CHEMBL260046 | EVOFOSFAMIDE | IC50 | = | 9080.0 | nM | 5.04 |