Assay Detail
Binding
CHEMBL4026835
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by fluorescently labeled tracer binding method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of 4-Phenoxyquinoline Based Inhibitors for L1196M Mutant of Anaplastic Lymphoma Kinase by Structure-Based Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.40 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL327980 | — | — | 1 | 8.92 |
| CHEMBL4087615 | — | — | 1 | 5.61 |
| CHEMBL4065208 | — | — | 1 | 5.56 |
| CHEMBL4091441 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL327980 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4087615 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL4065208 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL4091441 | — | IC50 | = | 3120.0 | nM | 5.51 |