Assay Detail
Binding
CHEMBL4026902
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]cytisine from alpha4beta2 nAChR expressed in human recombinant SH-SY5Y cell membranes after 120 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907589) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Structure-Based Design and Discovery of New M2 Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.33 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3 | NICOTINE | 4.0 | 1 | 8.82 |
| CHEMBL4083241 | — | — | 1 | 8.80 |
| CHEMBL4099673 | — | — | 1 | 6.70 |
| CHEMBL4060823 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3 | NICOTINE | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL4083241 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL4099673 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL4060823 | — | Ki | = | 9700.0 | nM | 5.01 |