Assay Detail
Binding
CHEMBL4026922
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His-tagged Escherichia coli beta-glucuronidase expressed in Escherichia coli BL21 (DE3) using pNPG as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Specific Inhibition of Bacterial β-Glucuronidase by Pyrazolo[4,3-c]quinoline Derivatives via a pH-Dependent Manner To Suppress Chemotherapy-Induced Intestinal Toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.82 | 7.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4102433 | — | — | 1 | 7.84 |
| CHEMBL4084481 | — | — | 1 | 7.75 |
| CHEMBL4078421 | — | — | 1 | 7.61 |
| CHEMBL4092228 | — | — | 1 | 7.53 |
| CHEMBL4063043 | — | — | 1 | 7.46 |
| CHEMBL4103626 | — | — | 1 | 7.43 |
| CHEMBL4086989 | — | — | 1 | 7.42 |
| CHEMBL4064529 | — | — | 1 | 7.26 |
| CHEMBL4061756 | — | — | 1 | 7.25 |
| CHEMBL4065549 | — | — | 1 | 7.01 |
| CHEMBL4083535 | — | — | 1 | 6.88 |
| CHEMBL4062030 | — | — | 1 | 6.87 |
| CHEMBL4068317 | — | — | 1 | 6.81 |
| CHEMBL4065558 | — | — | 1 | 6.62 |
| CHEMBL4086195 | — | — | 1 | 6.55 |
| CHEMBL4077288 | — | — | 1 | 6.51 |
| CHEMBL4086978 | — | — | 1 | 6.22 |
| CHEMBL4068253 | — | — | 1 | 6.21 |
| CHEMBL4084537 | — | — | 1 | 6.20 |
| CHEMBL4065186 | — | — | 1 | 6.17 |
| CHEMBL3903683 | — | — | 1 | 6.07 |
| CHEMBL4099232 | — | — | 1 | 6.05 |
| CHEMBL4073118 | — | — | 1 | 5.04 |
| CHEMBL1808316 | D-SACCHARIC ACID 1,4-LACTONE | — | 1 | - |
| CHEMBL4063721 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4102433 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL4084481 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4078421 | — | IC50 | = | 24.7 | nM | 7.61 |
| CHEMBL4092228 | — | IC50 | = | 29.6 | nM | 7.53 |
| CHEMBL4063043 | — | IC50 | = | 34.8 | nM | 7.46 |
| CHEMBL4103626 | — | IC50 | = | 37.3 | nM | 7.43 |
| CHEMBL4086989 | — | IC50 | = | 38.1 | nM | 7.42 |
| CHEMBL4064529 | — | IC50 | = | 55.3 | nM | 7.26 |
| CHEMBL4061756 | — | IC50 | = | 55.6 | nM | 7.25 |
| CHEMBL4065549 | — | IC50 | = | 98.2 | nM | 7.01 |
| CHEMBL4083535 | — | IC50 | = | 132.6 | nM | 6.88 |
| CHEMBL4062030 | — | IC50 | = | 136.5 | nM | 6.87 |
| CHEMBL4068317 | — | IC50 | = | 153.6 | nM | 6.81 |
| CHEMBL4065558 | — | IC50 | = | 238.2 | nM | 6.62 |
| CHEMBL4086195 | — | IC50 | = | 281.4 | nM | 6.55 |
| CHEMBL4077288 | — | IC50 | = | 307.8 | nM | 6.51 |
| CHEMBL4086978 | — | IC50 | = | 597.7 | nM | 6.22 |
| CHEMBL4068253 | — | IC50 | = | 613.1 | nM | 6.21 |
| CHEMBL4084537 | — | IC50 | = | 626.0 | nM | 6.20 |
| CHEMBL4065186 | — | IC50 | = | 673.3 | nM | 6.17 |
| CHEMBL3903683 | — | IC50 | = | 846.0 | nM | 6.07 |
| CHEMBL4099232 | — | IC50 | = | 884.2 | nM | 6.05 |
| CHEMBL4073118 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1808316 | D-SACCHARIC ACID 1,4-LACTONE | IC50 | > | 10000.0 | nM | - |
| CHEMBL4063721 | — | IC50 | > | 10000.0 | nM | - |