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Assay Detail

CHEMBL4027167

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of recombinant human full length HDAC6 expressed in fall armyworm Sf9 cells using fluorogenic ZMAL as substrate after 90 mins by fluorimetric analysis
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histone deacetylase 6 (CHEMBL1865)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity.
Heimburg T, Kolbinger FR, Zeyen P, Ghazy E, Herp D, Schmidtkunz K, Melesina J, Shaik TB, Erdmann F, Schmidt M, Romier C, Robaa D, Witt O, Oehme I, Jung M, Sippl W.
J Med Chem (2017) 60 : 10188 -10204
PubMed 29190092 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 5.18 5.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3797516 1 5.54
CHEMBL2381520 1 5.51
CHEMBL4066734 1 5.40
CHEMBL4074491 1 5.34
CHEMBL4061831 1 5.30
CHEMBL4101727 1 5.29
CHEMBL4105068 1 5.29
CHEMBL4080303 1 5.12
CHEMBL4099064 1 5.05
CHEMBL4089635 1 4.84
CHEMBL2170177 1 4.32
CHEMBL4081759 1 -
CHEMBL4059841 1 -
CHEMBL4094005 1 -
CHEMBL4073344 1 -
CHEMBL4093511 1 -
CHEMBL4079328 1 -
CHEMBL4077076 1 -
CHEMBL4097353 1 -
CHEMBL4075725 1 -
CHEMBL4065500 1 -
CHEMBL4087210 1 -
CHEMBL4095643 1 -
CHEMBL4093480 1 -
CHEMBL4065863 1 -
CHEMBL4077880 1 -
CHEMBL4095909 1 -
CHEMBL4085740 1 -
CHEMBL4103665 1 -
CHEMBL4084319 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3797516 IC50 = 2900.0 nM 5.54
CHEMBL2381520 IC50 = 3100.0 nM 5.51
CHEMBL4066734 IC50 = 4000.0 nM 5.40
CHEMBL4074491 IC50 = 4600.0 nM 5.34
CHEMBL4061831 IC50 = 5000.0 nM 5.30
CHEMBL4101727 IC50 = 5100.0 nM 5.29
CHEMBL4105068 IC50 = 5100.0 nM 5.29
CHEMBL4080303 IC50 = 7500.0 nM 5.12
CHEMBL4099064 IC50 = 8900.0 nM 5.05
CHEMBL4089635 IC50 = 14400.0 nM 4.84
CHEMBL2170177 IC50 = 48200.0 nM 4.32
CHEMBL4068505 IC50 - -
CHEMBL4081759 IC50 - -
CHEMBL4059841 IC50 - -
CHEMBL4094005 IC50 - -
CHEMBL4073344 IC50 - -
CHEMBL4093511 IC50 - -
CHEMBL4079328 IC50 - -
CHEMBL4077076 IC50 - -
CHEMBL4097353 IC50 - -
CHEMBL4075725 IC50 - -
CHEMBL4065500 IC50 - -
CHEMBL4087210 IC50 - -
CHEMBL4095643 IC50 - -
CHEMBL4093480 IC50 - -
CHEMBL4065863 IC50 - -
CHEMBL4077880 IC50 - -
CHEMBL4095909 IC50 - -
CHEMBL4085740 IC50 - -
CHEMBL4103665 IC50 - -
CHEMBL4084319 IC50 - -