Assay Detail
Functional
CHEMBL4027182
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Cytotoxicity against human BE(2)-C cells assessed as reduction in cell viability by measuring metabolic activity after 72 hrs by WST-8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BE(2)-C |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.80 | 4.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3797516 | — | — | 1 | 4.90 |
| CHEMBL4105068 | — | — | 1 | 4.80 |
| CHEMBL2170177 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3797516 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4105068 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL2170177 | — | IC50 | = | 19900.0 | nM | 4.70 |