Assay Detail
Binding
CHEMBL4027352
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Displacement of [3H]-CGP-39653 from NMDA receptor in Sprague-Dawley rat brain synaptosomes after 60 mins by scintillation counting method
16
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 5.40 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4084540 | — | — | 2 | 6.22 |
| CHEMBL4068651 | — | — | 2 | 6.22 |
| CHEMBL4099104 | — | — | 2 | 5.34 |
| CHEMBL4102488 | — | — | 2 | 4.78 |
| CHEMBL4081069 | — | — | 2 | 4.46 |
| CHEMBL4076785 | — | — | 1 | - |
| CHEMBL4091369 | — | — | 1 | - |
| CHEMBL4073502 | — | — | 1 | - |
| CHEMBL4083586 | — | — | 1 | - |
| CHEMBL4088958 | — | — | 1 | - |
| CHEMBL4060745 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4084540 | — | Ki | = | 602.56 | nM | 6.22 |
| CHEMBL4068651 | — | Ki | = | 602.56 | nM | 6.22 |
| CHEMBL4068651 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL4084540 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL4099104 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL4099104 | — | Ki | = | 4570.88 | nM | 5.34 |
| CHEMBL4102488 | — | Ki | = | 16595.87 | nM | 4.78 |
| CHEMBL4102488 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL4081069 | — | Ki | = | 35000.0 | nM | 4.46 |
| CHEMBL4081069 | — | Ki | = | 34673.69 | nM | 4.46 |
| CHEMBL4076785 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4091369 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4073502 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4083586 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4088958 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4060745 | — | Ki | > | 100000.0 | nM | - |