Assay Detail
Binding
CHEMBL4027656
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CrtN in methicillin-resistant Staphylococcus aureus LAC USA300 assessed as reduction in staphyloxanthin levels after 48 hrs by spectrophotometric method-based pigment inhibition assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus LAC |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming) (CHEMBL4105865) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus (strain USA300) |
Publication
Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.46 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4086008 | — | — | 1 | 8.72 |
| CHEMBL4101749 | — | — | 1 | 8.40 |
| CHEMBL3814424 | — | — | 1 | 8.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4086008 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4101749 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3814424 | — | IC50 | = | 5.5 | nM | 8.26 |