Assay Detail
Binding
CHEMBL4027658
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CrtN in methicillin-resistant Staphylococcus aureus NRS271 assessed as reduction in staphyloxanthin levels after 48 hrs by spectrophotometric method-based pigment inhibition assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.14 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4086008 | — | — | 1 | 8.25 |
| CHEMBL3814424 | — | — | 1 | 8.17 |
| CHEMBL4101749 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4086008 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL3814424 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4101749 | — | IC50 | = | 10.1 | nM | 8.00 |