Assay Detail
ADMET
CHEMBL4027660
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Cytotoxicity against human HepG2 cells after 43 hrs by Alamar blue dye-based fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.72 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 5.51 |
| CHEMBL4101749 | — | — | 1 | 4.66 |
| CHEMBL4062732 | — | — | 1 | 4.48 |
| CHEMBL4100870 | — | — | 1 | 4.22 |
| CHEMBL4086008 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4101749 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL4062732 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4100870 | — | IC50 | = | 60200.0 | nM | 4.22 |
| CHEMBL4086008 | — | IC50 | = | 105800.0 | nM | - |