Assay Detail
Binding
CHEMBL4027809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CrtN in Staphylococcus aureus Newman after 12 resistant development passages under 0.15% v/v H2O2 assessed as reduction in staphyloxanthin levels under IC90 level after 48 hrs by spectrophotometric method-based pigment inhibition assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus subsp. aureus str. Newman |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming) (CHEMBL3813586) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus (strain Newman) |
Publication
Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.67 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4086008 | — | — | 1 | 8.74 |
| CHEMBL4101749 | — | — | 1 | 8.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4086008 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4101749 | — | IC50 | = | 2.6 | nM | 8.59 |