Assay Detail
Binding
CHEMBL4027941
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant bacterial VIM-2 expressed in Escherichia coli BL21 (DE3) cells using FC4 as substrate preincubated for 10 mins prior to substrate addition in presence of Triton X-100 by fluorescence-based assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.82 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4083640 | — | — | 1 | 7.40 |
| CHEMBL4073235 | — | — | 1 | 7.16 |
| CHEMBL4092378 | — | — | 1 | 7.16 |
| CHEMBL4070942 | — | — | 1 | 7.00 |
| CHEMBL4070776 | — | — | 1 | 7.00 |
| CHEMBL4061012 | — | — | 1 | 6.82 |
| CHEMBL4098147 | — | — | 1 | 6.77 |
| CHEMBL4088105 | — | — | 1 | 6.77 |
| CHEMBL4096976 | — | — | 1 | 6.75 |
| CHEMBL4077989 | — | — | 1 | 6.75 |
| CHEMBL4088063 | — | — | 1 | 6.70 |
| CHEMBL4076158 | — | — | 1 | 6.64 |
| CHEMBL4065946 | — | — | 1 | 6.64 |
| CHEMBL4060980 | — | — | 1 | 6.44 |
| CHEMBL4069021 | — | — | 1 | 6.35 |
| CHEMBL4089287 | — | — | 1 | - |
| CHEMBL4079094 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4083640 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4073235 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4092378 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4070942 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4070776 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4061012 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4098147 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4088105 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4096976 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4077989 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4088063 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4076158 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4065946 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4060980 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4069021 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4089287 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4079094 | — | IC50 | > | 100000.0 | nM | - |