Assay Detail
Binding
CHEMBL4027945
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Inhibition of recombinant bacterial IMP-1 expressed in Escherichia coli BL21 (DE3) cells using FC4 as substrate preincubated for 10 mins prior to substrate addition in presence of Triton X-100 by fluorescence-based assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.56 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4070942 | — | — | 1 | 7.30 |
| CHEMBL4070776 | — | — | 1 | 7.22 |
| CHEMBL4092378 | — | — | 1 | 6.85 |
| CHEMBL4088105 | — | — | 1 | 6.75 |
| CHEMBL4073235 | — | — | 1 | 6.66 |
| CHEMBL4076158 | — | — | 1 | 6.64 |
| CHEMBL4077989 | — | — | 1 | 6.52 |
| CHEMBL4065946 | — | — | 1 | 6.52 |
| CHEMBL4096976 | — | — | 1 | 6.50 |
| CHEMBL4083640 | — | — | 1 | 6.43 |
| CHEMBL4088063 | — | — | 1 | 6.41 |
| CHEMBL4060980 | — | — | 1 | 6.41 |
| CHEMBL4061012 | — | — | 1 | 6.32 |
| CHEMBL4098147 | — | — | 1 | 6.10 |
| CHEMBL4069021 | — | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4070942 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4070776 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4092378 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4088105 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4073235 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4076158 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4077989 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4065946 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4096976 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4083640 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4088063 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4060980 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4061012 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4098147 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4069021 | — | IC50 | = | 1720.0 | nM | 5.76 |