Assay Detail
Binding
CHEMBL4027946
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant bacterial SPM-1 expressed in Escherichia coli BL21 (DE3) cells using FC5 as substrate preincubated for 10 mins prior to substrate addition by fluorescence-based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.11 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4077989 | — | — | 1 | 6.11 |
| CHEMBL4092378 | — | — | 1 | 6.11 |
| CHEMBL4070776 | — | — | 1 | 6.11 |
| CHEMBL4088063 | — | — | 1 | 6.11 |
| CHEMBL4065946 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4077989 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4092378 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4070776 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4088063 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4065946 | — | IC50 | = | 780.0 | nM | 6.11 |