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Assay Detail

CHEMBL4027951

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human DCLRE1A
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

DNA cross-link repair 1A protein (CHEMBL4105903)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.
Cain R, Brem J, Zollman D, McDonough MA, Johnson RM, Spencer J, Makena A, Abboud MI, Cahill S, Lee SY, McHugh PJ, Schofield CJ, Fishwick CWG.
J Med Chem (2018) 61 : 1255 -1260
PubMed 29271657 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 3.61 3.61

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4076158 1 3.61

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4076158 IC50 = 247000.0 nM 3.61