Assay Detail
Binding
CHEMBL4027962
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Binding affinity to human galectin 3 C-terminal domain expressed in Escherichia coli BL21(DE3) by competitive isothermal titration calorimetric analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 7.76 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4104417 | — | — | 1 | 8.77 |
| CHEMBL4102995 | — | — | 1 | 8.54 |
| CHEMBL4066068 | — | — | 1 | 8.49 |
| CHEMBL4091143 | — | — | 1 | 8.06 |
| CHEMBL4064035 | — | — | 1 | 7.96 |
| CHEMBL4077188 | — | — | 1 | 7.72 |
| CHEMBL4065371 | — | — | 1 | 7.68 |
| CHEMBL4085600 | — | — | 1 | 7.52 |
| CHEMBL4075335 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4104417 | — | Kd | = | 1.7 | nM | 8.77 |
| CHEMBL4102995 | — | Kd | = | 2.9 | nM | 8.54 |
| CHEMBL4066068 | — | Kd | = | 3.2 | nM | 8.49 |
| CHEMBL4091143 | — | Kd | = | 8.7 | nM | 8.06 |
| CHEMBL4064035 | — | Kd | = | 11.0 | nM | 7.96 |
| CHEMBL4077188 | — | Kd | = | 19.0 | nM | 7.72 |
| CHEMBL4065371 | — | Kd | = | 21.0 | nM | 7.68 |
| CHEMBL4085600 | — | Kd | = | 30.0 | nM | 7.52 |
| CHEMBL4075335 | — | Kd | = | 7400.0 | nM | 5.13 |