Assay Detail
Binding
CHEMBL4028141
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-aldosterone from human GST-tagged MR ligand binding domain after 4 hrs by liquid scintillation counting
16
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of Morpholino-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-ones as Nonsteroidal Mineralocorticoid Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.96 | 7.89 |
| Ki | 1 | 8.20 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2181928 | — | — | 2 | 8.20 |
| CHEMBL4086109 | — | — | 1 | 7.89 |
| CHEMBL4097160 | — | — | 1 | 7.89 |
| CHEMBL4064593 | — | — | 1 | 7.72 |
| CHEMBL4078214 | — | — | 1 | 7.41 |
| CHEMBL4100538 | — | — | 1 | 7.25 |
| CHEMBL4082524 | — | — | 1 | 7.07 |
| CHEMBL4098088 | — | — | 1 | 6.96 |
| CHEMBL4079143 | — | — | 1 | 6.95 |
| CHEMBL4059632 | — | — | 1 | 6.56 |
| CHEMBL4062345 | — | — | 1 | 6.40 |
| CHEMBL4062371 | — | — | 1 | 6.14 |
| CHEMBL4079083 | — | — | 1 | 5.93 |
| CHEMBL4071008 | — | — | 1 | 5.65 |
| CHEMBL4081584 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2181928 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL4086109 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4097160 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4064593 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2181928 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4078214 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4100538 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4082524 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4098088 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL4079143 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL4059632 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL4062345 | — | IC50 | = | 401.0 | nM | 6.40 |
| CHEMBL4062371 | — | IC50 | = | 727.0 | nM | 6.14 |
| CHEMBL4079083 | — | IC50 | = | 1181.0 | nM | 5.93 |
| CHEMBL4071008 | — | IC50 | = | 2225.0 | nM | 5.65 |
| CHEMBL4081584 | — | IC50 | > | 10000.0 | nM | - |